Second monitor cut off because it's blank at the moment
PSPad because notepad isn't enough, and Notepad++ doesn't play well with some programs/is bad. For notepad replacements i've literally tried them all, and this is the best one (and it's free)
Console2 because I always need a command prompt at my fingers, and it gives me an interesting looking wallpaper
xplorer² The least ghetto explorer replacement, so many things that explorer
should have, without some of the annoyances. Again, the least ghetto file manager i've found.
Foobar2000 even though you can't tell from the screenshot, I can easily sort and customize multiple playlists quickly and easily through a searchable database.
Sandboxie is a sandbox for your computer, lets you analyze a virus, or just protect yourself from one if you suspect a file might be infected.