Hmmm, for ultimate comfort to match your hand, why not a Cyborg R.A.T 9?
Pretty much every part of it can move and tilt in every direction so you can adjust it perfectly to fit your hand shape.
5600 DPI LASER, the red button is a precision aim button, differend modes, weights etc... you get the idea, it's immense.
http://cyborggaming.com/prod/rat9.htm For more in depth analysis.