If it's Vista compatible, it'll run... and if it doesn't run all you have to do is right-click the .exe, go to the compatibility tab, and choose the option to run the program in compatibility mode for Vista. If it's XP compatible but not Vista, just do the same and set it to compatibility for XP.
And if that doesn't work, then your shit out of luck until whoever made whatever it is your trying to run, puts out an update or new version.
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